Low Risk Prostate Cancer Patients Faces Dilemma
in Cancer News, People, Prevention, Prostate Cancer, Social Impact, Stress Reduction @ 9:10 am by Know Cancer NewsWASHINGTON — It took eight agonizing months for Charles Linzey to decide how to treat his early-stage prostate cancer. His wife, in contrast, had her early-stage breast cancer surgically removed just a month after diagnosis.
It’s not that the Baltimore businessman was less decisive. Instead, Linzey ran into a distressing reality: Unlike with breast cancer and many other malignancies, doctors simply couldn’t tell him which therapy was a better bet for the leading male cancer.
There is little good research directly comparing prostate treatment options to help the newly diagnosed choose between surgery, two types of radiation, or watching a small tumor to see if it needs treating at all.
“I never felt comfortable, even when I made my choice, with my choice. Because no one would say, ‘That’s a good choice,’” says Linzey, 59, who ultimately went with implanted radioactive “seeds” and is faring well.
Two new studies suggest the advice gap has consequences: overtreating early-stage tumors, and therapy choices driven by fear and misperceptions.
“When we give people choices, it’s sometimes more difficult,” acknowledges Dr. John B. Fiveash, a radiation oncologist at the University of Alabama, Birmingham, who is at the forefront of a fledgling trend to try to change that - through specialized prostate clinics.
Key for patients to know: “Not all prostate cancer is the same,” stresses Dr. John T. Wei, a University of Michigan urologist who recently reported that about 55 percent of men with low-risk tumors are overtreated, unnecessarily exposing them to such side effects as impotence and incontinence.
Certainly aggressive prostate cancer can kill. But often, prostate cancer is so slow-growing, and discovered when it’s so small, that men will die of something else before it ever causes symptoms, much less becomes life-threatening.
One man in every six will get prostate cancer, but only one in 34 will die of it, the American Cancer Society says.
That sounds reassuring until you’re the man wondering if you’ll be in the lucky majority or not. Unfortunately, doctors have no easy way to tell.
Adding to the confusion: Studies are contradictory about whether aggressive treatment really improves a low-risk man’s long-term chances of survival - or if a better option might be to closely monitor the tumor and treat it only if it starts to grow, so that he doesn’t endure side effects until he really has to.
And while some older studies do suggest that radiation and surgery recipients fare equally well for up to 10 years, Fiveash laments that there are no direct comparisons of more modern surgical and radiation techniques, including more precisely targeted, potentially safer ways to deliver radiation.
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