In previous studies there has not shown to be an increase in survival when adding chemotherapy after surgery for gastric cancer compared with surgery alone. Most U.S. patients that are diagnosed with cancer of the stomach or lower esophagus have locally advanced disease that is hard to cure.The MAGIC trial represents a landmark study in gastric cancer, as it is the first trial to demonstrate a survival benefit for pre- and postoperative chemotherapy. Researchers studied 503 patients with cancer of the stomach, esphagogastric junction or lower esophagus. One arm of the trial received three preoperative and three postoperative cycles of chemotherapy, the other arm of the study had only surgery.

The trial concluded that the chemotherapy group had smaller resectable tumors with negative margins, fewer patients had advanced nodal disease and the five year survival rate increased by 13 percent. It was noted that this is a significant advance for the treatment of this disease.

On October 23, seven-time Tour de France winner and testicular cancer survivor Lance Armstrong, with attend a day-long meeting in Lexington, Kentucky as a member of the President’s Cancer Panel to discuss the promotion of healthy lifestyles in reducing cancer risks. The President’s Cancer Panel was created by the National Cancer Act over thirty years ago to monitor and evaluate all aspects of the National Cancer Program. The Panel identifies and conducts inquiry into concerns and emerging issues in cancer-related science and cancer care. Members of the Panel include Armstrong; Dr. LaSalle Leffall; Margaret L. Kripke, Ph.D.; and Abby B. Sandler, Ph.D.

Dr. LaSalle Leffall is the Charles R. Drew Professor of Surgery, Howard University College of Medicine in Washington, DC, and Chairman of the Board of the Susan G. Komen Breast Cancer Foundation. Margaret L. Kripke, Ph.D., is Professor of Immunology and Executive Vice President and Chief Academic Officer of The University of Texas M.D. Anderson Cancer Center. Abby B. Sandler, Ph.D., Chief, Institute Review Office (IRO), National Cancer Institute (NCI), became Executive Secretary of the President’s Cancer Panel in January of 2005.

The meeting in Kentucky will focus on recommendations related to tobacco and exposure to indoor smoke. Researchers and experts will attend the meeting to join the discussions.