The American Cancer Society said it was looking for half a million volunteers willing to let researchers watch them for the next 20 years to see if they get cancer.

The aim is to match similar big studies in Europe and Asia that are looking on a large scale for the environmental and lifestyle factors that cause cancer, the second-leading cause of death in the United States after heart disease.

“This type of study involves hundreds of thousands of people, with diverse backgrounds, followed for many years, with collection of biological specimens and assessments of dietary, lifestyle and environmental exposures,” Eugenia Calle, managing director of analytic epidemiology at the American Cancer Society, said in a statement.

“It also requires active follow-up to discover if and when study participants develop cancer.”

The group will recruit men and women between the ages of 30 and 65 who have never been diagnosed with cancer. They will give blood to be tested and answer questionnaires at various times over the next 20 years.

Similar big studies have confirmed the link between cigarette smoking and lung cancer, shown that obesity increases the risk of several cancers, and linked aspirin use to a lower death rate from colon cancer.

They have also found evidence that defied conventional wisdom, such as the Women’s Health Initiative study that found hormone replacement therapy actually raises the risk of breast cancer, stroke and heart attack.

Cancer cases are expected to more than double between the years 2000 and 2030, says the director of the World Health Organization’s International Agency for Research on Cancer.

This upward climb will occur primarily in poor countries due to an increase in population growth, longer life expectancy, more smoking, and a lack of health care in low and medium-resource countries.

“What’s going to happen between now and 2030 is that the population is going to increase from about 6.5 billion to 8 billion in 2030,” Dr. Peter Boyle reports. “So even if the risks remain constant at each five-year age group, because we’ve got more people around, we’re going to have more cases of cancer.

It’s the unfortunate successes for developed countries over the past 40 years, such as the export of cigarette smoking and alcohol consumption, that have doomed poorer countries, says Boyle.

Consider this definition of doom: By the year 2030, there will be 27 million cases of cancer, 17 million deaths caused by the disease, and 75 million people living with cancer.

Doctors prescribing anemia drugs for patients with kidney disease and cancer were urged by the Food and Drug Administration (FDA) on Friday to carefully dispense of these drugs due to an increased risk of death and other serious problems, such as blood clots, strokes, and heart attacks in patients with chronic kidney failure and rapid tumor growth in patients with head and neck cancer who receive doses higher than recommended.

The potentially harmful drugs, sold under than brand names Procrit, Epogen, and Aranesp, are genetically engineered versions of a natural protein, called erythropoietin that increases the number of red blood cells. The drugs, with combined 2006 U.S. sales of $10 billion, are commonly used for patients with certain forms of kidney disease and for those receiving chemotherapy for cancer.

The FDA is adding warnings to the drugs’ labels that will strongly instruct doctors to use the lowest possible dose needed to help patients avoid blood transfusions.

The FDA will also take a close look at how the drugs are marketed, including claims the drugs can improve the quality of life.

A meeting of FDA officials to further discuss this issue, believed to stem from drug overuse by dialysis centers and oncologists who make more money by using more of the drugs. is scheduled for May 10. Recommendations could lead to additional revisions of the drugs’ labels.

Devastating blood born fungal infections that can be lethal for cancer, HIV/AIDS, and organ transplant patients may be treated more successfully, thanks to a new drug delivery method of Amphotericin B developed by researchers at the University of British Columbia in Vancouver. Because the oral form of the drug is easier to administer and cheaper than intravenous delivery more patients would have access to the medicine. Amphotericin B deoxycholate (AmBd) has been the gold standard for the treatment of systemic mycoses for the past 5 decades. The intravenous form of the drug caused severe kidney toxicity as well as serious tissue damage at the intravenous injection site. This research was triggered by clinicians needing a way to kill these fungal infections without risking the patient’s kidney. The new form can be can be taken by mouth with minimal side effects boosting effectiveness and dramatically reducing toxicity.

It was effective in treating Candida albicans an infection prevalent in HIV/AIDS and cancer patients receiving chemotherapy, and can cause symptoms ranging from cough to brain damage. Research funding for this project was provided by the Canadian Institutes of Health Research, Canada’s major agency responsible for funding health research. Composed of 13 Institutes, CIHR provides leadership and support to more than 10,000 health researchers and trainees across Canada.

Discoveries have linked certain viruses to cancer growth. The hepatitis B virus is related to liver cancer. Women who develop cervical cancer have had a human papilloma virus (HPV) infection but not all women with HPV infection will develop cervical cancer. Stomach ulcers are likely caused by Helicobactor pylori, or H. pylori a bacteria and the ulcers can grow into cancer. Viruses attack cells in the body and once these cells are corrupted they begin to grow uncontrollably, eventually leading to cancer.

With these discoveries leads us to the knowledge that protecting the immune system in the body and keeping viruses at bay, is important in preventing cancer. Viruses enter the body through everyday activities like eating, breathing and sexual activity. Eating well, exercising and avoiding alcohol and cigarettes are good ways to keep your body’s natural defenses functioning at their best. Staying protected with condoms during sexual intercourse helps protect you from sexually transmitted viruses and diseases. Learning healthy life style habits is the beginning of keeping cancer at bay. Focusing on nutrition, exercise, body weight, keeping toxins out of our bodies and our home environment ,and lowering stress will all help boost the immune system.

Actress Gwyneth Paltrow has lost five family members to cancer — and she fears the disease may one day strike her. So she’s taking action now and is trying to beat back the cancer curse that seems to loom over her loved ones.

Ever since losing her famous father in 2002 to throat cancer, Paltrow has been approaching life from a biological perspective.

“Cancer has been the curse of my family,”she said. “I am challenging these evil genes by natural means. I am convinced that by eating biological foods it is possible to avoid the growth of tumors. I began this crusade soon after my father’s death. Since then the fight against tumors has been my mission.”

Paltrow and her husband, Coldplay’s Chris Martin, have embraced a strict vegetarian diet for their young family, and they hope their commitment to healthy eating will ward off the illness they fear may be headed right for them.

Eating watercress every day could help protect against cancer, say researchers. Watercress, a leafy green vegetable favored in salads and soup, could be promoted to the rank of a super food alongside broccoli, blueberries, dark chocolate and baked beans, with new research suggesting it can help reduce the risk of cancer.  The vegetable also reduces damage to DNA in cells, according to a British trial.

The researchers discovered that DNA damage to white blood cells was reduced by 22.9%. Furthermore when exposed to dangerous chemicals, such as hydrogen peroxide, the damage was much lower than expected.

Importantly, antioxidant levels in the subjects also improved during the trial which help to combat free radicals that damage tissues. In contrast, harmful compounds in the blood decreased by 10%. Additionally the most beneficial effects were seen in smokers who participated in the study.

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ATLANTA – Pharmaceutical giant AstraZeneca is pledging $10 million to the American Cancer Society, the second-largest gift in the organization’s history, to help provide one-on-one support for cancer patients in U.S. hospitals, the American Cancer Society said Wednesday.

The society said the money will help it develop 50 new sites for its Patient Navigator Program. One of the first three sites was in AstraZeneca’s U.S. base of Wilmington, Del., at the Helen F. Graham Cancer Center at Christiana Care.

“While there are many uncertainties associated with cancer,” said Richard C. Wender, the national volunteer president of the American Cancer Society, “the Patient Navigator Program can relieve some of these anxieties by providing personalized support and education for the needs of each patient and their families.”

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The American Journal of Preventive Medicine issued a report that stated American cigarette warning labels are the smallest and have the least detail printed, making them the least effective.

Other countries such as Canada, Australia, and Britain have warnings that are much larger and include more health information appearing on both sides of the packages. Some countries even have very graphic warning labels printed on their cigarettes.

A study was conducted to see if these larger, more informed labels could make a difference. The study included 15,000 adult smokers in the U.S., U.K, Canada, and Australia to test the effectiveness of the warning labels used in those four countries between 2002 – 2005. The research did suggest that U.S. smokers might benefit from large graphic warnings on the packages. The U.S. smokers were least likely to notice their American labeling. The researchers also concluded that the U.S. warnings are poor compared to those in other countries. It is suggested that the U.S. labels need a makeover and putting quit-smoking resources on cigarette packages might also help.

In a radical new approach to attacking cancer, researchers will soon attempt to kill tumors by infecting them with viruses that cause ailments like the common cold.

This virus therapy treatment — considered the third pillar alongside chemotherapy and radiation — could one day become standard battle against cancer.

One Belfast doctor says anything that could improve the lives of cancer patients is worth a try. And try is exactly what Leonard Seymour, Professor of Gene Therapy at Oxford University, plans to do when he begins leading trials later this year.

Seymour, who has been working with viruses that kill cancer cells while sparing healthy tissue, will use a stealth virus masked from the body’s immune system with a polymer coat that could travel through the bloodstream and reach tumors.

Two viruses are likely candidates for study in the first clinical trials — adenovirus, cause of a cold-like virus, and vaccinia, cause of cowpox and a component in the smallpox vaccine.

Preliminary research on mice shows that virus therapy works well on tumors resistant to standard cancer drugs. But several years of trials will be necessary before the therapy can be considered for use on all cancers.